Cell Therapy Technology Platform
mRNADisTM enables rapid screening and discovery of highly selective and potent ScFv or VH domain antibody modules against therapeutic targets utilizing either soluble proteins or live cells for selection. Live cell selection is particularly valuable for generating antibodies binding to the disease relevant epitopes and challenging targets such as multi-transmembrane proteins. ScFv and VH domains can be further engineered to generate bispecific or multi-functional cellular or biologic modalities.
mSCAFoldTM is rationally design tailored libraries based on our understanding of the structure-function relationship between a target of interest and its interaction partner(s). We then utilize mRNA display technology to screen and identify engineered mutants with re-directed pharmacological properties (e.g. agonist or antagonist) for therapeutic applications. Our technology platform enables rapid protein engineering leading to proteins with specific mechanisms of action.
Discovery Platform Advantages
mRNADisTM
Fully Human Antibody Libraries
- Large diversity, 1013 natural human repertoire, lower immunogenicity
- Rapid generation of donor/disease-specific libraries
Live Cell Selections
- Generation of lead molecules recognizing native conformation desired epitopes
- Enabling identification of novel disease –specific epitopes
Human Library and Mammalian Display
- Enriching for soluble and stable antibodies for development
mSCAFoldTM
Rationally Designed Libraries
- Structural modelling
- Rationally designed large sized libraries
Epitope Directed Selections
- Enhancing desired functions
- Eliminating undesired functions
Novel Mechanism
- Extend therapeutic index
- More efficacious and safer candidate
Charles Zhao, M.D., MBA, brings more than 20 years of drug development experience in oncology therapeutic area. Before Elpis, Charles served as CMO at ABM Therapeutics and Sr. Medical Director at Mirati Therapeutics. Previously, he was Medical Director at EMD Serono working on cMET inhibitor global program in hepatocellular carcinoma indication; MEK inhibitor early phase development program in multiple indications including pancreatic cancer, ovarian cancer, melanoma, NSCLC, CRC, TNBC, and CML; and MetAP2 inhibitor early phase development program. He was Associate Medical Director at Boehringer Ingelheim working on PLK1 inhibitor in urothelial carcinoma and AML indication. His career highlights also include his work at Novartis working on HDAC inhibitor in CTCL and PKC inhibitor in AML indication, and Eli Lilly in early phase clinical development.
Diala Ezzeddine, Ph.D. Diala is founder and CEO of Xios Therapeutics (Waltham, MA), a privately held, venture-backed drug discovery company. Xios is developing next generation oncology protein degrading therapeutics with the potential to transform the treatment and lives of cancer patients. From 2010 to 2015, Diala was EVP and Chief Business Officer of X-Chem. She was instrumental in crafting the company’s business strategy, obtaining an equity investment, and establishing multiple revenue generating partnerships with top tier pharmaceutical companies with a cumulative deal value surpassing $2B. In the course of her career, Diala held business development roles of increasing responsibility at several leading biotechnology companies in the Boston area including Millennium Pharmaceuticals (Cambridge, MA, now Takeda Pharmaceuticals), and Archemix Corp. (Cambridge, MA). In support of the companies’ corporate strategies, she structured and negotiated value creating partnerships with several of the world’s largest pharmaceutical companies. Diala holds a Ph.D. in Genetics from Harvard Medical School obtained in 1997. Before that, she had conducted research in the Neurogenetics department at Massachusetts General Hospital (Boston, MA). She is the lead author on a publication describing successful in vivo pre-clinical proof-of-concept for an innovative genetic engineering approach to treating malignant brain tumors.
Ahmad is the Vice President of Business Development and Corporate Strategy. Previously, he held roles in business development and corporate strategy at Epizyme and Momenta Pharmaceuticals. His diverse drug development experience includes roles in management consulting, commercial strategy, corporate finance, and program and portfolio management. Ahmad started his career in drug discovery as a research scientist at Abbvie, Vertex and Chiron. He holds a B.S in Chemistry from University of Massachusetts, an M.S. in Pharmacology from Northeastern University, and an MBA from F.W. Olin College of Business at Babson College.
Yan Chen, PhD: Founder, President and CEO. Yan brings more than 20 years of expertise in both mRNA display technology and biologic drug discovery in the oncology disease area. She was Biotherapeutics Discovery Head at Juno Therapeutics in Boston and Senior Vice President of Research at X-Body Biosciences which was acquired by Juno in 2015. Previously, she was an investigator and project leader in Oncology Biotherapeutics at Novartis Institutes for Biomedical Research. Earlier in her career, she was a scientist at Phylos and Adnexus playing instrumental roles in establishing the mRNA antibody and protein display technology platforms. Yan was a postdoctoral trainee in Immunology at Tufts Medical School and received her PhD in Tumor Immunology from National University of Singapore. She is the co-inventor of more than 20 antibody technologies and biologic therapeutics patents.
Kehao Zhao, PhD: Co-founder, Chief Scientific Officer. Kehao brings more than 15 years of drug discovery experience in disease areas including cancer, liver disease and ophthalmology. Before Elpis, Kehao was a senior investigator at Novartis Institutes for Biomedical Research leading antibody therapeutics platform and cancer epigenetics research. Previously, Kehao was a scientist at Procter & Gamble Pharmaceuticals. Kehao completed postdoctoral training in Gene Expression & Regulation at the Wistar institute and received his PhD from the Institute of Biophysics at the Chinese Academy of Sciences. Kehao has published over 30 research papers in prestigious scientific journals.